In API and intermediate manufacturing industries, chemical synthesis takes place in reactors where normally requiring heating or cooling to facilitate the yield. Heat transfer media exchanges heat with reactants in jacket of reactors. Disadvantages of using primary refrigeration include safety and explosion risks (e.g. Ammonia) and environmental concerns (e.g. HCFC has high global warming potential). Use of freon us also not cost competitive especially in scenario of API manufacturing. CO2 involves high pressure operation, which is not suitable for batch process due to the instability of compressor for short period operation. It requires high purity of primary refrigerant (>99.5%) in close loop systems, which is a huge challenge for API manufacturing. Both low and high temperature operations can be required in chemical synthesis, leading to change over of primary refrigerant which further increases the system complexity. Therefore, secondary refrigeration is the best choice for API synthesis.
Common secondary refrigerants include glycol, brine, water and heating oil. One of the key issues for secondary refrigerant is corrosion, which can cause leakage and even equipment damage. Switching between low and high temperature heat transfer media might result in residue left in the system, impacting heat transfer performance and system operation.
Glacier coolant, our patented engineered heat transfer fluid, can either be utilized as low or high heat transfer media, with high anti-corrosion property and avoid the necessity of heat transfer media switching. It is the perfect choice for API and intermediate manufacturing.